|
KMID : 0624620140470110637
|
|
BMB Reports
2014 Volume.47 No. 11 p.637 ~ p.642
|
|
|
Sulodexide inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy
|
|
Jo Hyoung
Jung Sang-Hoon
Kang Jun
Yim Hye-Bin
Kang Kui-Dong
|
|
|
Abstract
|
|
|
|
Sulodexide is a mixed glycosaminoglycan composed of heparin and dermatan sulfate. In this study, the anti-angiogenic effect of sulodexide was investigated using an oxygen-induced retinopathy (OIR) mouse model. The retinas of sham-injected OIR mice (P17) had a distinctive central area of nonperfusion, and this area was significantly decreased in sulodexide-injected mice. The number of neovascular tufts measured by SWIFT_NV and mean neovascular lumen number were significantly decreased in sulodexide-injected mice. Hyperbaric oxygen exposure resulted in increased levels of VEGF, MMP-2 and MMP-9, and when mice were treated with sulodexide, a dose-dependent reduction in VEGF, MMP-2 and MMP-9 levels was observed. Our results clearly demonstrate the anti-angiogenic effect of sulodexide and highlight sulodexide as a candidate supplementary substance to be used for the treatment of ocular pathologies that involve neovascularization.
|
|
|
KEYWORD
|
|
|
Angiogenesis, MMP, Retinopathy, Sulodexide, VEGF
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|